Projects and Current Studies

BowelScope: Accuracy of Detection using ENdocuff Optimisation of Mucosal Abnormalities (B-ADENOMA) ARC Medical Ltd. CI: Professor Colin Rees. 

With the aid of the colonoscopic cuff Endocuff Vision®, this study aims to improve visualisation of the colonic mucosa by flattening colonic folds and manipulating them away from the field of forward view.  The hypothesis is that the Endocuff Vision® will improve adenoma detection rates by providing better fold retraction, a wider field of view and better scope tip stabilisation. This clinical randomised study will be conducted in subjects referred and scheduled for screening flexible sigmoidoscopy via the NHS English Bowel Scope Screening (BSS) Programme and will compare Endocuff Vision®-Assisted Flexible Sigmoidoscopy (EAFS) with Standard Flexible Sigmoidoscopy (SFS).

Can hygiene-therapists improve oral health of routine low-risk dental recall patients in 'High-street' dental practices: a pilot study. NIHR HS&DR. CI: Professor Paul Brocklehurst.  

The aim of this study is to inform the design for a definitive trial to determine whether hygiene therapists can maintain the oral health of "low-risk" routine NHS patients, who form the predominant proportion of the regularly attending practice population.

CARer-ADministration of as-needed sub-cutaneous medication for breakthrough symptoms in home-based dying patients: a UK study (CARiAD) NIHR HTA. CI: Professor Clare Wilkinson.

Undertaking a feasibility study and external randomised pilot trial of carer-administered as-needed sub-cutaneous medication for common breakthrough symptoms in home-based dying patients, versus usual care, with a nested qualitative component.

Dementia Carers Instrument Development: DECIDE. MRC CI: Dr Penny Wright.

The aim of this study is to develop and undertake psychometric evaluation of a quality of life measure for use with carers of people with dementia. This measure, once developed, will be called the ‘Carer QoL in Dementia’ (CQD). The CQD (the measure) will be designed for use with carers of people with dementia who are living in the community, including those in sheltered or extra-care housing.

Development and refinement of a Stroke friendly Oral health Promoting (STOP) toolkit to improve oral self-care after discharge from hospital stroke services. NIHR RfPB.  CI: Professor Craig Smith.

The aim of this research is to develop an intervention for stroke survivors to improve oral health by supporting oral self-care behaviours.

Evaluating the impact of a joint social care and NHS initiative. H&CRW.  CI: Dr Carys Jones.

This is a realist evaluation of the Health Precinct project in Conwy which will develop an explanatory theory of "what works, for whom, why and in what contexts" for related programmes that seek to integrate social and health care services to enable social participation. In addition, it will quantify the social return on investment generated by the programme.

IDEAL - Living well with dementia. ESRC. CI: Professor Linda Clare. 

This longitudinal cohort study aims to characterise the social and psychological factors that support or constrain the ability of participants with dementia and their carers to live well with any type of dementia. This will result in an action plan intended to assist policy-makers, purchasers and providers to develop evidence-based policies and practices aimed at preventing or reducing unnecessary disability, preserving independence, reducing the economic burden for families and for society, and maintaining well-being across the dementia disease trajectory, in order to allow more people with dementia to live well, and all people with dementia to live better.

Impact of a change to remuneration on the technical efficiency of dental practices: evaluation of the pilots of a new NHS Dental Contract in Northern Ireland. NIHR HS&DR. CI: Professor Paul Brocklehurst.

This study examines whether a new way of paying NHS general dental practitioners in Northern Ireland leads to differences in the activity and quality of dental care provided.

Mentalization for Offending Adult Males: A Randomised Controlled Trial (MOAM). NIHR HTA. CI: Professor Peter Fonagy.

This is a multi-site randomized control trial conducted in the NHS setting to investigate whether, in a sample of offenders under community supervision who meet DSM-5 criteria for antisocial personality disorder, Probation as usual (PAU) supplemented with mentalization based therapy is more effective and cost effective than the standard care pathway of PAU only.

Promoting Activity, Independence and Stability in Early Dementia (PRAISED). NHIR PGfAR. CI: Professor Rowan Harwood. 

This programme of work will develop and evaluate an intervention to promote activity, and independence, and preventing falls, for people with early dementia and mild cognitive impairment. It will study ways of promoting uptake and adherence to the intervention and will undertake a feasibility trial to test the intervention in practice, and prepare for a definitive multi-centred randomised controlled trial.

Respiratory Health in Preterm Neonatal Outcomes (RHINO).  MRC. CI: Professor Sailesh Kotecha.

This study identifies breathing disorders in 7-12 year old children who were born prematurely and tests if any airway obstruction responds to a single dose of inhaled drug typically used for asthma and related disorders. It will also use MRI scanning technology to study the lung structure and function in prematurely-born children with marked airway obstruction.

Water Assised Flexible Sigmoidoscopy in National Bowel Scope Screening (WASh) NIHR RfPB. CI: Professor Matt Rutter.

To reduce the risk of bowel cancer, the NHS Bowel Cancer Screening Programme invites 55 year olds for a sigmoidoscopy. This research will assess whether using water to minimise bowel distension, instead of gas, will make the procedure more comfortable. If proven effective in UK practice, the research team hope that by reducing pain, people will have a better experience, which may increase public participation in screening. Currently only 43.7% of people participate –more cancers could be prevented if participation is increased.